Extended Data Fig. 7: Repopulation potential by adult stem and fetal progenitor cells in mdx-NSG mice.
From: Regenerating human skeletal muscle forms an emerging niche in vivo to support PAX7 cells
Related to Fig. 5b. a. Myofiber formation of engrafted fetal SMPCs (500,000/injection, N = 6) and adult SCs (30,000/injection, N = 10). Graph shows mean ± SEM max number of engrafted myofibers, T-test, * = P = 0.02. b. Representative images (top) and quantification (below) show mean ± SD of PAX7+ repopulation potential from fetal SMPCs and adult SCs at 30 days, 60 days * = P < 0.0001, and after reinjury (day 60+RI) * = P < 0.0002. Inset shows representative locations of human (PAX7+LaminAC+) or mouse (PAX7+LaminAC-) muscle cells relative to chimeric or human-only myofibers.
