Extended Data Fig. 5: Cytosolic dsDNA accumulation induces cGAS-STING signalling.
From: Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders
(a, b) An increase in the accumulation of dsDNA was detected (a, as dsDNA puncta, indicated by yellow arrows) and quantified (b, n = 40 dsDNA puncta pooled from 4 mice in each group) in Gla-/- mice DRGs by immunostaining. Scale bars, 100 μm (left), 50 μm (right). Scale bars, 100 μm. Error bars in graph b represent mean ± SEM, and P values were calculated by one-way ANOVA with Bonferroni correction.
