Extended Data Fig. 7: Overview of ER proteome remodeling via ER-phagy receptors during neurogenesis in vitro.

a, Changes in the abundance (Log₂FC) of the ER proteome (267 detected proteins) during conversion in ATG12^−/− or combinatorial ER-phagy receptor knockout iNeurons (day 12) are shown as heatmaps. Annotations of the type of ER protein are indicated by the relevant colours. b, Landscape of the ER proteome and the effect of deletion of five ER-phagy receptors (FAM134A/B/C, TEX263 and CCPG1) on accumulation of individual proteins. The ER proteome (359 proteins, Supplementary Data Table 1) is organized into functional modules, and protein attributes (involved in ER membrane curvature, ER-associated, ER-membrane, ER-Lumen or ER-phagy receptor) are indicated by the respective outline box colour (see inset legend). For proteins with transmembrane segments, the number of segments is indicated after the protein name (_1, _2, etc) based on data in Uniprot. The text of each protein name is colored based on day12 PKO vs WT Log₂FC (see inset legend). (Supplementary Data Table 3).