Extended Data Fig. 10: Proposed model of peri-implantation signaling activity and anterior specification.
From: Distinct pathways drive anterior hypoblast specification in the implanting human embryo
a, Proposed model of BMP, NODAL and NOTCH signaling activity in the Hypoblast (top) and Epiblast (bottom) during human peri-implantation. Note implantation as a switch point in the activity of pathways for the epiblast, and a point of divergence of subpopulations within the hypoblast. The role of NOTCH in the hypoblast remains less clear, indicated by a gradient. b, Summary of signaling perturbation effects on human anterior hypoblast (top) and mouse distal/anterior visceral endoderm (DVE/AVE; bottom) specification. Schematics of human embryos correspond to day 5, day 7, and day 9 and mouse embryo schematics correspond to E3.5, E5.0, E5.75.
