Extended Data Fig. 1: Generation of combined cynomolgus monkey dataset.
From: Distinct pathways drive anterior hypoblast specification in the implanting human embryo
a, Uniform Manifold Approximation Projection (UMAP) of cynomolgus monkey scRNA-seq datasets colored by original publication. N = 10221 single cells. b, UMAP of monkey datasets colored by age of embryo. c, UMAP of monkey datasets colored by assigned cell type. d, UMAPs of monkey datasets colored by a gradient indicating gene expression for canonical markers of epiblast (EPI), hypoblast (HYPO), extraembryonic mesenchyme (EXMC), primitive streak, and trophectoderm/trophoblast (TE/TrB). Extraembryonic mesenchyme markers are also plotted on human dataset. e, Heatmap of average WikiPathways signaling pathway module score split by cell type and stage. Visualized value is calculated average scaled score from individual single-cell module scores. Gene names were converted from mfac to hgnc gene symbols for module scoring.
