Extended Data Fig. 4: Spatiotemporal dynamics of RNAPII, RNAPI and RNAPIII. | Nature Cell Biology

Extended Data Fig. 4: Spatiotemporal dynamics of RNAPII, RNAPI and RNAPIII.

From: Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

Extended Data Fig. 4

a, Fraction of free and bound in nucleoplasm (NPL) and nucleolus (NOL) (n = 100 resamplings; mean value ± s.d.). b, Distribution (area normalized) of free RNAPII, RNAPI and RNAPIII in nucleoplasm and nucleolus (n = 100 resamplings; mean value ± s.d.). c, Simulation of Nucleoplasm/Nucleolus distribution. d, Diffusion coefficients and molecular weights of free RNAPII, RNAPI and RNAPIII in nucleoplasm (n = 100 resamplings; mean value ± s.d.). e,f IUPRED3 disorder scores for the largest subunit of e, RNAPI (Rpa190) and f, RNAPIII (Rpo31). Residues with predicted scores above 0.5 considered disordered. g, Dfree of RNAPII and CTD mutants in nucleoplasm (n = 100 resamplings; mean value ± s.d.). Source numerical data are available in source data.

Source data

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