Extended Data Fig. 4: The genomic distribution of upregulated genes is similar to that of ZGA genes.
From: Transcription bodies regulate gene expression by sequestering CDK9
a. Distribution of upregulated genes (mir430-/- + inj MiR430 vs. WT at 256c) across the genome (as in Fig. 2c). The mir430 locus on chromosome 4 is shown in green and a zoom of its surrounding area is shown at the bottom of the panel. b. The enrichment (Observed vs. Expected) of genes shown in (a) on each chromosome. Significant enrichment was calculated using the hypergeometric distribution, and P-values were corrected for multiple testing with the Benjamini-Hochberg method. Significant enrichment (adjusted P-value < 0.05) is shown as blue bars. c. Distribution of ZGA genes (three classes: upregulated in WT 1024c vs. 256c, WT Oblong vs. 256c and WT Sphere vs. 256c) across the genome. d. The enrichment (Observed vs. Expected) of genes shown in (c) on each chromosome. Significant enrichment was estimated using the hypergeometric distribution, and P-values were corrected for multiple testing with the Benjamini-Hochberg method. Significant enrichment (adjusted P-value < 0.05) is shown as blue bars. Source numerical data are available on GEO (GSE248237).
