Extended Data Fig. 5: Alternative promoter usage is associated with driver transcription factors. | Nature Cell Biology

Extended Data Fig. 5: Alternative promoter usage is associated with driver transcription factors.

From: Integrative analysis of ultra-deep RNA-seq reveals alternative promoter usage as a mechanism of activating oncogenic programmes during prostate cancer progression

Extended Data Fig. 5

a, b) Unibind results showing significance of overlap between transcription factor (TF) ChIP-seq peaks and upregulated APs in localized PCa (A) or mCRPC (B). Each dot represents one ChIP-seq dataset. TFs were ranked by the most significant ChIP-seq dataset. P values were calculated using Fisher’s exact tests. Y axis shows the p values without multi-test adjustments, but the horizontal dashed line shows the corresponding BH-adjusted p value 0.05. c) Pathway enrichment analysis of genes with APs upregulated in mCRPC vs benign prostate and overlapping with MYC ChIP-seq peaks in LNCaP cells. P values were calculated using hypergeometric tests. X axis shows the p values without multi-test adjustments, but the coloring was based on BH-adjusted p values. Dashed line shows unadjusted p value 0.05.

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