Extended Data Fig. 3: VARS expression correlates negatively with the survival of patients with melanoma.
From: Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
a, Volcano plot representing translation factors (initiation and elongation) from M395 SENS and RES proteomics data. Significant changes (two-tailed unpaired t-test) are represented in red (upregulated genes) or in blue (downregulated genes). b, Quantification of VARS protein expression in M395, MM099 and MM029 SENS and RES cultures (Fold mean ± SEM of 2 independent replicates). c, VARS mRNA expression across cancers. TPM stands for transcripts per million. SKCM stands for skin cutaneous melanoma. d, TCGA analysis of all aminoacyl-tRNA synthetases expression in normal (N) and tumor (T) skin cutaneous melanoma. Pvalues were obtained from GEPIA.
