Extended Data Fig. 1: Overall translation rate is comparable in SENS and RES cultures.
From: Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
a, Polysome profiling experiments of M395 SENS and RES cultures and b, Global rates of mRNA translation reported by total cell OP-puro fluorescence in M395, MM074 and A375 SENS and RES cultures (fold mean ± SEM of at least 3 independent replicates, two-tailed unpaired t-test was performed). c, Dot plot of significantly enriched terms in RES using the hallmark database (GSEA). The color of the bubbles represents the FDR q-value and the size of the bubbles represents the enrichment score (NES). d, Heatmap representing amino acids enrichment analysis of proteins downregulated in M395 RES compared to the global genome Significant differences are represented whereas red indicates an enrichment and blue an impoverishment (chi-squared test was performed). Colour bar, fold change.
