Extended Data Fig. 2: GTG codon is the most represented valine codon in the human transcriptome.
From: Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma
a, Heatmap representing the z-scores of significantly modified tRNA isodecoders (by tRNA sequencing) in M395 SENS and RES cultures (n = 3 independent replicates). tRNA expression profiling is annotated with gene symbol and anticodon. Red is used to highlight tRNA-Val-CAC isodecoder genes. b, Correlation between significant changes in codons from the CCA (chi-squared test) and the downregulated tRNA isoacceptors (Two-tailed unpaired t-test, no adjustment was used for these comparisons), Blue, impoverished codons and decrease in the corresponding isoacceptors tRNAs; red, enriched codons and the corresponding isoacceptors tRNAs; c, Histogram representing frequency distribution of valine codons in the human genome. d, Quantification of tRNA-Val-CAC in MM029 SENS and RES cultures (fold mean ± SEM of 3 independent replicates, two-tailed unpaired t-test was performed).
