Extended Data Fig. 1: Primary loss of function screen identifies context-specific and non-specific circRNAs.
From: Systematic loss-of-function screens identify pathway-specific functional circular RNAs
(a) Overlap between circRNAs profiled in this study and circRNAs that were profiled in previous prostate specific circRNA screens10. (b) Distribution of proliferation changes following shRNA mediated knockdown of core-essential genes. (c) Comparison of proliferation changes (average fold change across all cell lines) in the 939 overlapping circRNAs from this study and from Chen et al.10 pValue calculated using Pearson correlation. (d) Pearson correlation in proliferation changes observed following suppression of the circRNA or the linear mRNA using shRNAs or CRISPRs. Gene dependency scores were taken from DepMap61. (e) Volcano plots showing two class comparisons that identify pathway and lineage specific circRNAs. pValue calculated using a one tail T.test with unequal variance. Source numerical data (C,D,E) are available in source data.
