Extended Data Fig. 3: Multi-view modelling prediction performance per target in spatially resolved metabolite-transcriptome data.
From: LIANA+ provides an all-in-one framework for cell–cell communication inference
A) Top 10 metabolite peaks with the highest variance explained (R2), including Dopamine (in dark red) and 3-methoxytyramine (3-MT) peaks, as annotated in the original publication26. B) Relative contributions of views (receptors and cell types) when jointly predicting metabolite peak intensities. C) Contributions of each view in predicting dopamine. Error bars represent 95% confidence intervals around the mean. The displayed P-value was calculated using a two-sided paired t-test across replicates (n = 3). D-F) Differences between lesioned and intact hemispheres in Dopamine’s canonical Drd2 receptor, and medium MSN cell types 1 and 2. Uncorrected P-values were calculated using one-sided paired t-tests across replicates. The central line within each box marks the median, with the box hinges representing the first and third quartiles. The whiskers extend up to 1.5 times the interquartile range above and below the box hinges. Source numerical data are available in source data.
