Whether the telomerase protein TERT has moonlighting functions by acting catalytically in telomere elongation and non-catalytically in extratelomeric functions has long been debated. A study now demonstrates that TERT can regulate physiological levels of inflammatory signals independently of its catalytic functions.
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Ye, J., Gilson, E. Noncatalytic telomerase function in inflammation. Nat Cell Biol 27, 1206–1207 (2025). https://doi.org/10.1038/s41556-024-01497-6
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DOI: https://doi.org/10.1038/s41556-024-01497-6
