Fig. 5: GABPA regulates a common set of EPI genes in E4.5 ICM and ES cells.
From: The transcription factor GABPA is a master regulator of naive pluripotency
a, Heatmaps showing the DEGs in 2iES cells after dTAG13 treatment for 24 h, and the GABPA binding GABPA motif occurrence around the TSS of the indicated gene groups. b, Heatmaps showing similar GABPA binding peaks in E4.5 ICM and 2iES cells. Two replicates were merged for GABPA binding analysis in E4.5 ICM and ES cells. c–e, A comparison of the DEGs (c), downregulated ICM genes (d) and downregulated EPI genes (e) between E4.5 ICM and 2iES cells after dTAG13 treatment. RNA-seq and GABPA CUT&RUN analysis were performed using two independent biological replicates. b, d and e show the pooled results of the two biological replicates in each condition.
