Extended Data Fig. 5: Cells isolated from C865S ‘knock-in’ mice showed defect of innate immune responses to infection with RNA virus. | Nature Cell Biology

Extended Data Fig. 5: Cells isolated from C865S ‘knock-in’ mice showed defect of innate immune responses to infection with RNA virus.

From: Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing

Extended Data Fig. 5

a, Heatmap showing colour-coded intensity levels of IFN target genes in SeV-stimulated Rig-IWT/WT and Rig-IC865S/C865S MEFs. n = 2 biologically independent samples. b, GSEA showing the most significant downregulated pathways in SeV-stimulated Rig-IC865S/C865S MEFs, as compared with the control wild-type MEFs. The data are derived from two repeated experiments, and the P values were calculated based on 1,000 permutations of the GSEA algorithm and were not adjusted for multiple comparisons. NES, normalized enrichment scores.

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