Fig. 2: The density for the head-to-tail contact is present in the Nup133−/− mES NPC.
From: Nuclear pores safeguard the integrity of the nuclear envelope
a–d, The head-to-tail contact between the CR (a) and NR (b) protomers of the wild-type mES NPC, and the CR (c) and NR (d) protomers of the Nup133−/− mES NPC. The CR and NR models of dilated human NPC (PDB 7R5J) are fitted into the corresponding cryo-EM maps. Nup93 and Nup205 molecules involved in the head-to-tail contact at the centre of the images are highlighted in bold colours. The main interaction interfaces are highlighted with red arrowheads. In a and c, the model of Nup358 is omitted for clarity. In b, the basket filament position is highlighted (green arrowhead).
