Fig. 1: MB primary and metastatic tumour cells are functionally distinct. | Nature Cell Biology

Fig. 1: MB primary and metastatic tumour cells are functionally distinct.

From: Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth

Fig. 1

a, A schematic representation of mouse Ptch-SB primary tumour and spinal leptomeninges with metastasis (n = 4 mice) and Ptch-WT non-tumour spinal leptomeninges (n = 3 mice) collected for scRNA-seq. b, UMAP plot of cells from Ptch-SB cerebellar primary tumours with TME denoted as primary (tumour + TME), and spinal leptomeninges with metastasis denoted as LPT-MET (tumour + TME). c,d, UMAP plots of annotated cell populations from LPT-MET (tumour + TME) samples (c) and primary (tumour + TME) samples (d). e, A dot plot with expression across cell types of the top five markers by log fold change (MAST test, log fold change (LFC) >0.25, minimum percent expression >0.1). f, Gene Ontology (GO) terms associated with genes differentially expressed in primary and LPT-MET tumour cells. The circle sizes correspond to the number of differentially expressed genes found in each pathway (Holm FWER <0.05). See Supplementary Table 1 for the full gene list and pathways. ER, endoplasmic reticulum.

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