Extended Data Fig. 7: Meningeal fibroblast cluster changes across metastatic leptomeningeal burden. | Nature Cell Biology

Extended Data Fig. 7: Meningeal fibroblast cluster changes across metastatic leptomeningeal burden.

From: Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth

Extended Data Fig. 7

a, Pie charts showing the proportion of cell populations within the leptomeningeal samples of non-tumour bearing Ptch-WT mice (non-tumour LPT-WT1, 2, 3) and Ptch-SB mice with low metastatic burden (Low LPT-MET1, 2), and higher metastatic burden (High LPT-MET1, 2). b, Pie charts showing the proportion of LMF1-LMF7 clusters within the meningeal fibroblasts associated with non-tumour LPT-WT, low LPT-MET, and high LPT-MET samples. c, Dot plot showing the Myofibroblastic, Inflammatory, Antigen presenting and General CAF signature expression in the meningeal fibroblasts associated with LPT-WT, low LPT-MET, and high LPT-MET samples. d, GO terms associated with the genes differentially expressed in the meningeal fibroblasts associated with LPT-WT, low LPT-MET, and high LPT-MET samples. The circle sizes correspond to the number of differentially expressed genes found in each pathway (Holm family-wise error rate (FWER) < 0.05). See Supplementary Table 3 for full gene list and pathways.

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