Fig. 4: Meningeal fibroblast heterogeneity in the metastatic niche. | Nature Cell Biology

Fig. 4: Meningeal fibroblast heterogeneity in the metastatic niche.

From: Metastatic medulloblastoma remodels the local leptomeningeal microenvironment to promote further metastatic colonization and growth

Fig. 4

a, UMAP plot of meningeal fibroblast recluster from Ptch-WT control leptomeninges (LPT-WT) and Ptch-SB leptomeninges with metastasis (LPT-MET) samples. b, GO terms associated with the genes differentially expressed in meningeal fibroblasts from LPT-WT and LPT-MET samples. The circle sizes correspond to the number of differentially expressed genes found in each pathway (Holm FWER <0.05). See Supplementary Table 2 for the full gene list and pathways. c, UMAP plot of meningeal fibroblast recluster identities (LMF1–LMF7) from LPT-WT and LPT-MET samples. d, Pie charts showing the proportion of LMF1–LMF7 clusters in LPT-WT and LPT-MET samples. e, GO terms enriched in the LPT-MET LMF1 cluster (P values were generated using g:Profiler’s Significance Correction Strategy (gSCS))40. f, A dot plot showing the myofibroblastic, inflammatory, antigen-presenting and general CAF signature expression in LMF1–LMF7 clusters.

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