Extended Data Fig. 4: Changes in enhancer and promoter activity in response to mechano-osmotic stimuli.
From: Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells
(a) Heatmaps of pseudo-bulk ATAC-seq, H3K4me3 and H3K27ac Cut & Tag at annotated H3K27ac peaks, further classified into active promoters and putative active enhancers, illustrating expected enrichment of histone modifications and chromatin accessibility at promoters and enhancers. Log2 fold change (FC) heatmaps highlight H3K27ac changes at active promoters and enhancers across different conditions compared to the pluripotency medium condition. (b) Reactome pathway enrichment of decommissioned enhancers specific to hypertonic shock (Fisher’s exact /Benjamini-Hochberg). Source numerical data are available in source data.
