The AMP-dependent protein kinase AMPK is thought to be activated only when cellular energy levels are low. However, a study now finds that intracellular AMP is generated from extracellular adenosine in an intricate growth signalling cascade, explaining how AMPK can be regulated by extracellular cues.
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Rumpf, S., Sanal, N. AMPK signalling integrated in growth control. Nat Cell Biol (2025). https://doi.org/10.1038/s41556-025-01777-9
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DOI: https://doi.org/10.1038/s41556-025-01777-9
