Extended Data Fig. 2: Single-step photobleaching confirms detection of individual probes. | Nature Chemistry

Extended Data Fig. 2: Single-step photobleaching confirms detection of individual probes.

From: Single-molecule visualization of DNA G-quadruplex formation in live cells

Extended Data Fig. 2

a, 25 pM SiR-PyPDS binding to MYC in vitro. The red square indicates a single binding event. b, Intensity traces from three binding events in (a), showing probes undergoing single-step photobleaching. The insets show time lapses for each molecule. Similar single-step photobleaching could be consistently observed in all single-molecule video acquisitions.

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