Fig. 2: A general strategy for synthesizing O-acetylated sialosides. | Nature Chemistry

Fig. 2: A general strategy for synthesizing O-acetylated sialosides.

From: Synthetic O-acetylated sialosides facilitate functional receptor identification for human respiratory viruses

Fig. 2

a, Chemically synthesized 4,7,9-tri-O-acetylated common precursors for HE-mediated regioselective de-O-acetylation. The biotinylated anomeric linker is denoted as R. b, Methods for chemoenzymatic remodelling of the common precursors. BCoV and MHV-S HEs regiospecifically cleave 9- and 4-O-acetyl groups, respectively. c, The glycosyl donor and acceptors for chemical assemblies of 1–3a. See Supplementary Fig. 2 for the preparation of glycosyl acceptors. Nap, 2-naphthyl.

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