Extended Data Fig. 6: One-pot reaction of malonate with glyoxylate in the presence of cyanide leading to the formation of isocitrate. | Nature Chemistry

Extended Data Fig. 6: One-pot reaction of malonate with glyoxylate in the presence of cyanide leading to the formation of isocitrate.

From: Cyanide as a primordial reductant enables a protometabolic reductive glyoxylate pathway

Extended Data Fig. 6

Time course 1H-NMR of the reaction of malonate with glyoxylate (a) after 4 days which shows the formation of intermediates 16 and 30 and (b) after 35 days showing the formation of isocitrate isomers 12 and its lactone isomers 12a. See also Supplementary Figs. 69-70.

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