Extended Data Fig. 8: Complex structure of BurG co-crystallized with gonydiol (5) (PDB ID: 7PCN).
From: Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead
The 2FO-FC electron density maps (grey meshes, contoured to 1.0 σ) and the FO-FC maps (green meshes, contoured to 3.0 σ) are depicted for the respective ligand. a. 6 and DMS (shadowed in grey) have been omitted for phasing. b. 14 (shadowed in grey) has been omitted for phasing. The FO-FC electron density maps clearly depict the excluded ligands, proving that 14, 6 and DMS are all bound to the active site. The occupancy of each ligand was set to 0.5. E232 is located on subunit B and marked in pink.
