Extended Data Fig. 2: Synthesis of aliphatic hydroxy acid AcK-OH and aromatic hydroxy acids pIF-OH and NapA-OH.
From: Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
Reagents and conditions: 3. AcK, NaNO2, AcOH, H2O, RT, 52% yield; 4. pIF, NaNO2, AcOH, H2O, RT, 47% yield; 5. NapA, NaNO2, AcOH, H2O, RT, 47% yield.
