Extended Data Fig. 2: Modelling the specificity of homoMV particles for single mutant targets.
From: Heteromultivalency enables enhanced detection of nucleic acid mutations
a, Scheme showing binding pathway of a homoMV particle binding either a SNP-containing target or a WT target and modification of binding affinity equation with MM factor. b, Predicted arbitrary signals when a homoMV particle with different affinities binds the SNP target or the WT target. c, Predicted discrimination factors for a homoMV particle with different affinities. Red dots correspond to discrimination factors for six values of Keq chosen to mimic a series of oligos of length x, x + 1, …, x + 5 nt. The black dashed curve was generated by fitting the predicted values to a gaussian distribution in GraphPad.
