Fig. 3: Synthetic routes to classes B–H.
From: A divergent intermediate strategy yields biologically diverse pseudo-natural products
a, Access to classes B–H from class A. The relative configuration of B10 was determined by X-ray crystallography (Supplementary Information), and the structures of other products (including class C) were drawn by analogy. Diastereomeric ratios of class B were determined by 1H nuclear magnetic resonance. For individual diastereomeric ratios, see Supplementary Information. b, Synthesis of classes F, G and H from 1 and 5, respectively, utilizing the NH of indole derivatives. Isolated yields are shown. Parent NP examples and the corresponding NP fragments from which the PNPs are derived are shown on the right side of the figures. RT, room temperature; CFL, compact fluorescent lamp; fan, 3 W cooling fan.
