Fig. 1: Chiral molecules, resolution reactions and enantioconvergent reactions.

a, Examples of chiral molecules in which the absolute configuration is critical to their function. b, Resolution reactions, which are inherently limited to a maximum 50% yield (A is starting material, R* is a chiral reagent, P is product). c, Established approaches to achieving enantioconvergent reactions (A is starting material, B is an intermediate, P is product). d, A stereoretentive approach to enantioconvergent reactions (A is starting material, AA is a chiral non-meso product). e, Stereoretentive enantioconvergent heterochiral dimerization. f, Stereoretentive enantioconvergent multicomponent reaction using an unsymmetrical linker molecule (represented as ◑).