Fig. 3: Kinetic modelling for multicomponent stereoretentive enantioconvergent reactions.

a, Envisaged reaction manifold for a multicomponent stereoretentive enantioconvergent reaction, using an asymmetric linker molecule (◑), with example of statistical amplification of enantiopurity for a poorly selective initial KR (s = 8). b, Statistical amplification of enantiopurity (that is, Horeau amplification) over a representative range of selectivity factors in the initial KR (1 < s < 100). c, Parameters used for the kinetic modelling: (1) simple second-order kinetics for both steps; (2) the coupling step is much slower than the initial KR (k₁ ≫ k₂); and (3) there is no asymmetric induction in the second step (k_2-hetero = k_2-homo). More complex reaction kinetics and/or asymmetric induction in the second step could result in stereoisomeric ratios different from those predicted. Full details of the kinetic modelling are described in section 7 of the Supplementary Information. d, One of Horeau’s original reactions exhibiting statistical amplification of enantiopurity.