Fig. 5: Investigating triple-stereodifferentiation effects in multicomponent diastereoconvergent reactions using enantiopure linkers.
Identification of a triple-stereodifferentiation effect using (R)/(S)-propylene glycol 22 as the asymmetric linker in a diastereoconvergent reaction of racemic phenylalanine N-carboxyanhydride 23 using (DHQD)2AQN as catalyst. DMAP, 4-(dimethylamino)pyridine; Et2O, diethyl ether. ae.e. values were determined from the corresponding methyl esters, after hydrolysis and methylation using KHCO3 and CH3I; for full details, see section 5 of the Supplementary Information.
