Determining the ligandability of the human proteome can provide key insights to characterize biological processes and promote drug discovery. Now, multi-tiered activity-based protein profiling provides comprehensive proteomic maps of chiral small-molecule interactions. Over 300 distinctive proteins were identified to ligand tryptoline acrylamides, including stereoselective and site-specific events.
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Pezacki, J.P., Lundrigan, E., Evers, P. et al. Charting the ligandable proteome for stereoselective interactions. Nat. Chem. 16, 1571–1573 (2024). https://doi.org/10.1038/s41557-024-01639-1
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DOI: https://doi.org/10.1038/s41557-024-01639-1
