Extended Data Fig. 1: Assessment of the putative G4switches.
From: Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch
a, Calculated physicochemical properties of PDS and the putative G4switches. Values highlighted in bold italics indicate violation of Lipinski’s rule of five: clog D, partition coefficient (≤ 5); n OHNH, number of hydrogen bond donors (≤ 5); n ON, number of hydrogen bond acceptors (≤ 10); Polar surface area (80 – 140 Å2); Molecular weight (≤ 500 Da). b, Structure verification of 5 μM G4 MYC (G-runs are highlighted in bold) and dsDNA control used in the FID assay by CD. Mean of three scans (n = 3) is shown.
