Extended Data Fig. 8: 19F-13C and HCF-TROSY reveal Olaparib binding to PARP1. | Nature Chemistry

Extended Data Fig. 8: 19F-13C and HCF-TROSY reveal Olaparib binding to PARP1.

From: Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins

Extended Data Fig. 8

(a) 19F-13C TROSYs of 400 μM protonated [4-19F13Cζ; 3,5-2H2ε] Phe-labelled PARP1 in presence (navy) and absence (pink) of 400 μM Olaparib. (b) HCF-TROSYs of the samples shown in (a) following the same colour code. One small negative peak (noise) is shown in grey.

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