Extended Data Fig. 8: Crystal structures of BbmA-ThDP-HPPA and BbmAG484F-ThDP-CBOA-covalent, and structural comparisons of the active sites. | Nature Chemistry

Extended Data Fig. 8: Crystal structures of BbmA-ThDP-HPPA and BbmAG484F-ThDP-CBOA-covalent, and structural comparisons of the active sites.

From: Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions

Extended Data Fig. 8

a, The structure of BbmA-ThDP-HPPA with two monomer molecules in one asymmetric unit. b, The structure of BbmAG484F-ThDP-CBOA-covalent shown with two monomer molecules. c, Structural comparison between the active sites of BbmA-ThDP (residues in cyan and ThDP in yellow) and BbmAG484F-ThDP-CBOA-covalent (residues in light pink and ThDP-CBOA-covalent in blue). d, Structural comparison between the active sites of BbmA-ThDP-HPPA (residues in magenta and ThDP in yellow) and BbmAG484F-ThDP-CBOA-covalent (residues in light pink and ThDP-CBOA-covalent in blue).

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