Extended Data Fig. 1: HKAS-catalyzed α-keto acids coupling reactions in the biosynthesis of various natural products.

The red and blue moieties of the α-hydroxy-β-keto acids are derived from acyl donor and acceptor substrates, respectively.
The red and blue moieties of the α-hydroxy-β-keto acids are derived from acyl donor and acceptor substrates, respectively.