Tauopathies are neurodegenerative diseases characterized by the pathological aggregation of tau, which forms distinct polymorphic structures in a disease-specific manner. A recent study presents macrocyclic tau-mimicking peptides that structurally and functionally resemble these disease-associated folds, providing new tools for studying tau aggregation and potential therapeutic strategies.
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Schymkowitz, J., Rousseau, F. Mimicking the structure and function of tau folds associated with disease. Nat. Chem. 17, 793–794 (2025). https://doi.org/10.1038/s41557-025-01841-9
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DOI: https://doi.org/10.1038/s41557-025-01841-9
