Nina M. Allen, Guilherme A. Marczak Giorio and M. Carmen Galan discuss how select napthalene diimides, such as QN-302, have been developed into DNA G-quadruplex (G4) ligands with downstream anticancer activity.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$32.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bhosale, S. V. et al. Chem. Soc. Rev. 50, 9845–9998 (2021).
Neidle, S. J. Med. Chem. 59, 5987–6011 (2016).
Ahmed, A. A. et al. ACS Med. Chem. Lett. 11, 1634–1644 (2020).
Verma, A., Yadav, V. K., Basundra, R., Kumar, A. & Chowdhury, S. Nucleic Acid Res. 37, 4194–4204 (2009).
Prorok, P. et al. Nat. Commun. 10, 3274 (2019).
Huppert, J. L. & Balasubramanian, S. Nucleic Acid Res. 35, 406–413 (2007).
Tosoni, B. et al. Med. Chem. Res. 33, 2030–2049 (2024).
Pirota, V., Nadai, M., Doria, F. & Richter, S. N. Molecules 24, 426 (2019).
Cuenca, F. et al. Bioorg. Med. Chem. Lett. 18, 1668–1673 (2008).
Figueiredo, J., Mergny, J. L. & Cruz, C. Life Sci. 340, 122481 (2024).
Micco, M. et al. J. Med. Chem. 56, 2959–2974 (2013).
Ahmed, A. A. et al. Molecules 28, 2452 (2023).
Pérez-Soto, M. et al. Bioorg. Med. Chem. 71, 116946 (2022).
Street, S. T. G. et al. Chem. Eur. J. 23, 6953–6958 (2017).
Platella, C., Napolitano, E., Riccardi, C., Musumeci, D. & Montesarchio, D. J. Med. Chem. 64, 3603 (2021).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Allen, N.M., Marczak Giorio, G.A. & Galan, M.C. Naphthalene diimides for G4s. Nat. Chem. 17, 1296 (2025). https://doi.org/10.1038/s41557-025-01870-4
Published:
Issue date:
DOI: https://doi.org/10.1038/s41557-025-01870-4
