Fig. 3: Further aspects of heteropropellane chemistry. | Nature Chemistry

Fig. 3: Further aspects of heteropropellane chemistry.

From: Hetero[3.1.1]propellanes

Fig. 3

a, Re-formation of propellanes from diiodo hetero-BCHeps and hetero-[2]staffanes. b, Examples of 3-aza[3.1.1]propellanes with alternative groups on the nitrogen, which are installed at the penultimate step of propellane synthesis. c, Application of 3-oxa[3.1.1]propellane to the synthesis of oxa-BCHep-sonidegib (22). d, Detosylation of aza-BCHep 18ac. TMEDA, N,N,N’N’-tetramethylethylenediamine; HATU, hexafluorophosphate azabenzotriazole tetramethyl uronium.

Back to article page