Table 2 Substrate scope of bioactive molecules and dienophiles

From: Formal Diels–Alder reaction of saturated carboxylic acids via C–H activation

  1. aAcid (2 equiv.), maleimide-fluorescein (1 equiv.) was added. bReaction conditions: HFIP (0.1 ml), xylene (1.0 ml), 4.0 equiv. LiCl, 160 °C, 18 h. cReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 2.0 equiv. NaH2PO4, 150 °C, 18 h. dReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 150 °C, 18 h. eReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), 1.0 equiv. KH2PO4, acid 5 equiv., vinylphenylketone 1 equiv., 160 °C, 18 h. fReaction conditions: HFIP (0.5 ml), xylene (0.5 ml), acid 5 equiv., methyl acrylate 1 equiv., Pd(OAc)2 were used as catalysts, 160 °C, 18 h.
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