Extended Data Fig. 1: Predicted protein structures for selected candidate loci.
From: Convergent molecular evolution among ash species resistant to the emerald ash borer
a, Predicted protein structure for OG36502, modelled using the protein sequence for Fraxinus platypoda. The serine/asparagine variant at the site where convergence was detected is highlighted; the serine is a putative phosphorylation site. b, Predicted protein structure for OG40061, modelled using the protein sequence for F. mandshurica. The asparagine/serine variant at the site where convergence was detected is highlighted; the serine is a putative phosphorylation site. The putative substrate, NADP, is shown docked within the predicted active site. c, Predicted protein structure for OG38407, modelled using the protein sequence for F. mandshurica. The aspartic acid/asparagine variant at the site where convergence was detected is highlighted; the site falls within a leucine rich repeat region (LRR; shaded blue) which is predicted to span from position 111–237 within the protein sequence (detected using the GenomeNet MOTIF tool (www.genome.jp/tools/motif/), searching against the NCBI-CDD and Pfam databases with default parameters; the LRR region was identified as positions 111–237 with an e-value of 1e-05). d, Predicted protein structure for OG21033, modelled using the protein sequence for F. platypoda. The lysine/glutamine at the site where convergence was detected is highlighted. The putative substrate, β-D-Glcp-(1 → 3)-β-D-GlcpA-(1 → 4)-β-D-Glcp, is shown docked within the predicted active site.
