Extended Data Fig. 5: Signature attributions based on 21 paired BL/PD biopsies from the Prospect-C trial using MutationalPatterns and deconstructSigs.
From: Mutational signatures impact the evolution of anti-EGFR antibody resistance in colorectal cancer
a, Mutation signature attribution using independent decomposition methods (deconstructSigs and MutationalPatterns). b, Fig. 2 repeated with the ‘fit_to_sigs’ function in MutationalPatterns to assess the variability of estimates between methods.
