Extended Data Fig. 5: Genomic distribution of derived substitutions across the ASIP locus.
From: Dog colour patterns explained by modular promoters of ancient canid origin
a, Canid phylogenies for the ventral (48 kb) and hair cycle (16 kb) promoter regions, with relevant internal branches marked by the occurrence of derived variants plotted in (b). b, Derived substitutions shared by grey wolf and dogs (cyan). Ancestral alleles on DY/Arctic wolf haplotypes (red) or BB and DY/Arctic wolf haplotypes (orange) that correspond to derived substitutions among the core group of wolf-like canids (Supplementary Table 12). The broken lines demarcate the HCP region (chr24:23,375,800–23,380,000). The solid line signifies the downstream boundary for phylogenetic analysis. The solid green and orange lines indicate the positions of the SINE and 24 bp insertion, respectively, associated with the DY/Arctic wolf haplotype.
