Fig. 5: Distribution of ASIP alleles in ancient dogs and wolves, and an evolutionary model for dominant yellow acquisition.
From: Dog colour patterns explained by modular promoters of ancient canid origin
a, ASIP haplotypes were inferred from WGS of five ancient dogs (circles), two ancient wolves (squares) and 68 modern wolves (pie charts) distributed across the Holarctic (Extended Data Fig. 7 and Supplementary Table 12 show detailed haplotype representations). Asterisks indicate SY/DY haplotypes for which the HCP1 insertion is either absent (SY*) or not ascertainable (DY*). b, A model for the origin of the dominant yellow haplotype and its transmission into dogs and Arctic wolves, in which molecular alterations at modular promoters were acquired by introgression (red, HCP1) or by mutation in the grey wolf (blue, VP1). The timelines for speciation events, dog domestication and geological events affecting grey wolf dispersal are based on prior studies10,33.
