Extended Data Fig. 10: Evolutionary replay in silico.
(a) Schematic figure for description of evolutionary replay. (b) Spatial maps of subclones over time in a representative in-silico tumour under Surface Growth with \(p_{driver} = 2 \times 10^{ - 4}\). (i)-(iv) mark historical tumour states selected as starting points for evolutionary replay. (c) Spatial maps of subclones at the end of two evolutionary replays that use (i)-(iv) in (b) as starting states. (d) Shannon diversity index at the end of evolutionary replays that start with different historical tumour states. From left to right reflect increasing sizes at which historical tumour states were collected for evolutionary replay. (e-f) Evolutionary replay performed based on in-silico tumours under Surface Growth (e) and under Volume Growth with \(p_{driver} = 6 \times 10^{ - 4}\), respectively. Dashed line in grey in panels (d-f) reflects the reference Shannon diversity index at the end of the original simulation.
