Extended Data Fig. 1: CTX concentrations during the evolution experiment.
CTX concentrations during the evolution experiment based on daily 20.25-fold increases when the OD600 was higher than 75% of the ancestral value without CTX (see text). Red lines represent small populations (S), blue lines large populations (L). Shades and line types have been varied randomly to better distinguish replicate populations. Note that for one large population the CTX concentration was increased during every round of passaging, as the cultures always reached a high density. For two other large populations, this was the case on all but one round of passaging.
