Extended Data Fig. 10: Population-scaled recombination rates in major venom regions.
From: The roles of balancing selection and recombination in the evolution of rattlesnake venom
Population-scaled recombination rate (ρ = 4Ner) across SVMP (a), SVSP (b), and PLA2 (c) venom gene regions in C. viridis and C. oreganus. Upper panels show chromosome-wide variation and lower panels show variation within the venom regions, specifically, highlighted by the grey shading in all panels. Dark blue segments in lower panels show the locations of venom paralogues. The light purple segment in c is the non-venom homologue PLA2gIIE. Shaded points in the upper panels of a-c represent mean ρ in 10 kb windows and black lines represent 100 kb windowed means. In lower panels of a and b, points and lines represent 1 kb and 10 kb windowed ρ. In lower panels of c, lines represent 1 kb windowed ρ and points are estimates from all SNP intervals. Vertical dashed lines show the locations of inferred recombination hotspots from Schield et al. (2020). Panels at the bottom show regional variation in the proportion of C. viridis (orange dashed line) and C. oreganus (dark blue line) individuals per population with evidence of copy-number variation (% CNV) across the venom gene regions.
