Extended Data Fig. 5: FCY1 evolutionary rate and orthologous residue diversity.
a) frequency of the S. cerevisiae amino acid at each position in the orthologous sequences. b) Normalized evolutionary rate for all Fcy1 residues (Rate4site24) from 215 orthologues. The blue line represents the rolling average over a 6 amino acid window. This statistic represents the rate at which amino acids change along a phylogeny: higher values represent more variable positions, while lower values represent more conserved positions. c) Multiple sequence alignment coverage of S. cerevisiae Fcy1 positions in the set of orthologues. The maximum value is 215, representing perfectly conserved amino acids positions across all sequences.
