Table 1 Summary of the model’s parameters and their biologically significant ranges

From: Evolution of resistance to COVID-19 vaccination with dynamic social distancing

Parameter

Symbol

Biologically significant range

References/notes

Basic reproductive ratio of WT

RWT

[1.8, 3.6]

68

Basic reproductive ratio of MT

RMT

[1.8, 3.6]

[3.6, 8] (more infectious variants)

68,69

Recovery rate

a

[0.08, 0.38]

70

Social distancing parameter

s

[0.05, 1]

–

Probability of death upon infection

d

[0.005, 0.02]

1

Population size

N

>106

–

Partial immunity coefficient

q

[0, 1]

–

Probability of resistance mutation

μ

<10−6

The probability is the composite probability of mutation from a vaccine-sensitive phenotype to a vaccine-resistant phenotype. See ‘Estimating the mutation probability, µ’ for the estimate.

Number of vaccinated

c

[0, 10,000]

1

Number of infected

L

[10, 1,000]

1

  1. The mutation rate refers to the probability that someone infected with the WT strain gives rise to someone infected with a vaccine-resistant strain. Hence, its value is different from the SARS-CoV-2 molecular mutation rate that occurs during one replication cycle. The number of vaccinated c and the number of infected L are given in per day per million. The population size is given in people count. The recovery rate is given per day. All other parameters are dimensionless.
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